5 it serves as a permeability barrier against the transdermal absorption of various chemical and kumar d sharma n rana ac agarwal g bhat za a review transdermal drug delivery system a tools for novel drug delivery sestem int j drug dev res 20113370 84 ramteke kh dhole sn patil sv transdermal drug delivery system a review j advanced sci res 20123122 35 yadav v . Transdermal drug delivery offers a number of advantages for the patient due not only its non invasive and convenient nature but also factors such as avoidance of first pass metabolism and prevention of gastrointestinal degradation it has been demonstrated that microneedle arrays can increase the number of compounds amenable to transdermal delivery by penetrating the skins protective . Heparin based delivery systems have been explored to improve their therapeutic efficacy and to reduce toxicity for different administration routes regardless of the applied drug delivery system dds the evaluation of anticoagulant performance is instrumental for the development of a suitable dds the understanding of the range of anticoagulant assays together with their key applications . Polymer drug conjugates belong to the category of polymer therapeutics and correspond to a novel approach towards efficient drug delivery systems polymer drug conjugates are placed under the class of nanodrug delivery systems in which chemical coupling via covalent bonding is achieved between hydrophilic polymers and drug molecules through . Altogether fundamental knowledge of chemical modifications to nucleic acids and advances in drug delivery systems led to the following first clinical approvals of sirna therapeutics the lipid
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